1
5
10
15
25
30
35
40
45
50
55
65
70
75
80
85
90
99
Protease
R41K
P39E
N37Q
M36I
E35N
E34N
A22V
K20C
Q18H
I15V
I13A
T12I
V11I
L10V
Q7D
T4P
R57K
D60H
Q61D
I62V
L63T
I64V
C67E
H69K
A71V
I72Q
I85L
L89I
Q92G
I93L
1
20
40
65
85
110
130
155
175
200
220
245
270
290
315
335
390
560
Reverse transcriptase
I195L
E194P
V179E
I178M
D177E
Q174N
S163T
I142V
I135V
K122E
V118C
K104Q
K103R
K102Q
A98G
V60I
I50V
K43Q
T39Q
E36A
V35T
K32E
E28R
T27S
E6A
G196A
Q197E
T200K
I202V
E204L
Q207E
L210Y
R211K
V241I
V245Q
E248N
S251V
V261I
A272Q
K275R
Q278E
L283I
A288S
I293V
T296S
E297K
A304E
I309K
D320Q
S322D
I326W
A327V
E328N
Q334E
I341V
E344D
P345E
F346H
M357Q
R358K
G359A
A360S
V365I
K366R
T369A
A371L
I375A
A376S
T377Q
T386L
I393V
Q394T
K395R
T403A
E404D
N418S
V423I
K431T
E449D
D460E
R461Q
R463K
V467I
S468K
T470D
D471E
T477A
Q480M
H483L
G490K
L491E
E492K
Q507S
A508S
D511T
K512Q
E514D
E516P
L517I
S519Q
Q524E
I526T
K527R
E529D
K530Q
A534T
Q547K
V548I
A554K
G555D
K558R
1
15
30
50
65
80
100
115
130
150
165
180
200
215
230
250
265
288
Integrase
Q137H
K136T
A133T
V126M
T125A
S119P
T112I
G106A
Y83F
L74I
L63M
I60V
G59E
K46R
L45I
Q44H
D41P
V37I
N27G
M22L
E11D
K7Q
D3E
K160S
G163Q
I182V
Y194C
S195T
I200L
V201I
I203M
I204L
T206S
D207Q
K211T
T218L
N222K
L234I
K240Q
N254K
S255G
K273Q
D278T
V281M
D286T
D288S